                         SEQUENCE LISTING

<110>  AMGEN INC.
       VIRCA, G. Duke
       HU, Shaw-Fen Sylvia
 
<120>  ANTIGEN BINDING PROTEINS THAT BIND PAR-2

<130>  A-1290-WO-PCT

<140>  -to be assigned-
<141>  2008-06-26

<150>  US 60/947,264
<151>  2007-06-29

<150>  US 61/058,094
<151>  2008-06-02

<160>  43    

<170>  PatentIn version 3.4

<210>  1
<211>  1194
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1191)

<400>  1
atg cgg agc ccc agc gcg gcg tgg ctg ctg ggg gcc gcc atc ctg cta       48
Met Arg Ser Pro Ser Ala Ala Trp Leu Leu Gly Ala Ala Ile Leu Leu         
1               5                   10                  15              

gca gcc tct ctc tcc tgc agt ggc acc atc caa gga acc aat aga tcc       96
Ala Ala Ser Leu Ser Cys Ser Gly Thr Ile Gln Gly Thr Asn Arg Ser         
            20                  25                  30                  

tct aaa gga aga agc ctt att ggt aag gtt gat ggc aca tcc cac gtc      144
Ser Lys Gly Arg Ser Leu Ile Gly Lys Val Asp Gly Thr Ser His Val         
        35                  40                  45                      

act gga aaa gga gtt aca gtt gaa aca gtc ttt tct gtg gat gag ttt      192
Thr Gly Lys Gly Val Thr Val Glu Thr Val Phe Ser Val Asp Glu Phe         
    50                  55                  60                          

tct gca tct gtc ctc act gga aaa ctg acc act gtc ttc ctt cca att      240
Ser Ala Ser Val Leu Thr Gly Lys Leu Thr Thr Val Phe Leu Pro Ile         
65                  70                  75                  80          

gtc tac aca att gtg ttt gtg gtg ggt ttg cca agt aac ggc atg gcc      288
Val Tyr Thr Ile Val Phe Val Val Gly Leu Pro Ser Asn Gly Met Ala         
                85                  90                  95              

ctg tgg gtc ttt ctt ttc cga act aag aag aag cac cct gct gtg att      336
Leu Trp Val Phe Leu Phe Arg Thr Lys Lys Lys His Pro Ala Val Ile         
            100                 105                 110                 

tac atg gcc aat ctg gcc ttg gct gac ctc ctc tct gtc atc tgg ttc      384
Tyr Met Ala Asn Leu Ala Leu Ala Asp Leu Leu Ser Val Ile Trp Phe         
        115                 120                 125                     

ccc ttg aag att gcc tat cac ata cat ggc aac aac tgg att tat ggg      432
Pro Leu Lys Ile Ala Tyr His Ile His Gly Asn Asn Trp Ile Tyr Gly         
    130                 135                 140                         

gaa gct ctt tgt aat gtg ctt att ggc ttt ttc tat ggc aac atg tac      480
Glu Ala Leu Cys Asn Val Leu Ile Gly Phe Phe Tyr Gly Asn Met Tyr         
145                 150                 155                 160         

tgt tcc att ctc ttc atg acc tgc ctc agt gtg cag agg tat tgg gtc      528
Cys Ser Ile Leu Phe Met Thr Cys Leu Ser Val Gln Arg Tyr Trp Val         
                165                 170                 175             

atc gtg aac ccc atg ggg cac tcc agg aag aag gca aac att gcc att      576
Ile Val Asn Pro Met Gly His Ser Arg Lys Lys Ala Asn Ile Ala Ile         
            180                 185                 190                 

ggc atc tcc ctg gca ata tgg ctg ctg att ctg ctg gtc acc atc cct      624
Gly Ile Ser Leu Ala Ile Trp Leu Leu Ile Leu Leu Val Thr Ile Pro         
        195                 200                 205                     

ttg tat gtc gtg aag cag acc atc ttc att cct gcc ctg aac atc acg      672
Leu Tyr Val Val Lys Gln Thr Ile Phe Ile Pro Ala Leu Asn Ile Thr         
    210                 215                 220                         

acc tgt cat gat gtt ttg cct gag cag ctc ttg gtg gga gac atg ttc      720
Thr Cys His Asp Val Leu Pro Glu Gln Leu Leu Val Gly Asp Met Phe         
225                 230                 235                 240         

aat tac ttc ctc tct ctg gcc att ggg gtc ttt ctg ttc cca gcc ttc      768
Asn Tyr Phe Leu Ser Leu Ala Ile Gly Val Phe Leu Phe Pro Ala Phe         
                245                 250                 255             

ctc aca gcc tct gcc tat gtg ctg atg atc aga atg ctg cga tct tct      816
Leu Thr Ala Ser Ala Tyr Val Leu Met Ile Arg Met Leu Arg Ser Ser         
            260                 265                 270                 

gcc atg gat gaa aac tca gag aag aaa agg aag agg gcc atc aaa ctc      864
Ala Met Asp Glu Asn Ser Glu Lys Lys Arg Lys Arg Ala Ile Lys Leu         
        275                 280                 285                     

att gtc act gtc ctg gcc atg tac ctg atc tgc ttc act cct agt aac      912
Ile Val Thr Val Leu Ala Met Tyr Leu Ile Cys Phe Thr Pro Ser Asn         
    290                 295                 300                         

ctt ctg ctt gtg gtg cat tat ttt ctg att aag agc cag ggc cag agc      960
Leu Leu Leu Val Val His Tyr Phe Leu Ile Lys Ser Gln Gly Gln Ser         
305                 310                 315                 320         

cat gtc tat gcc ctg tac att gta gcc ctc tgc ctc tct acc ctt aac     1008
His Val Tyr Ala Leu Tyr Ile Val Ala Leu Cys Leu Ser Thr Leu Asn         
                325                 330                 335             

agc tgc atc gac ccc ttt gtc tat tac ttt gtt tca cat gat ttc agg     1056
Ser Cys Ile Asp Pro Phe Val Tyr Tyr Phe Val Ser His Asp Phe Arg         
            340                 345                 350                 

gat cat gca aag aac gct ctc ctt tgc cga agt gtc cgc act gta aag     1104
Asp His Ala Lys Asn Ala Leu Leu Cys Arg Ser Val Arg Thr Val Lys         
        355                 360                 365                     

cag atg caa gta tcc ctc acc tca aag aaa cac tcc agg aaa tcc agc     1152
Gln Met Gln Val Ser Leu Thr Ser Lys Lys His Ser Arg Lys Ser Ser         
    370                 375                 380                         

tct tac tct tca agt tca acc act gtt aag acc tcc tat tga             1194
Ser Tyr Ser Ser Ser Ser Thr Thr Val Lys Thr Ser Tyr                     
385                 390                 395                             


<210>  2
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Ser Pro Ser Ala Ala Trp Leu Leu Gly Ala Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ala Ser Leu Ser Cys Ser Gly Thr Ile Gln Gly Thr Asn Arg Ser 
            20                  25                  30          


Ser Lys Gly Arg Ser Leu Ile Gly Lys Val Asp Gly Thr Ser His Val 
        35                  40                  45              


Thr Gly Lys Gly Val Thr Val Glu Thr Val Phe Ser Val Asp Glu Phe 
    50                  55                  60                  


Ser Ala Ser Val Leu Thr Gly Lys Leu Thr Thr Val Phe Leu Pro Ile 
65                  70                  75                  80  


Val Tyr Thr Ile Val Phe Val Val Gly Leu Pro Ser Asn Gly Met Ala 
                85                  90                  95      


Leu Trp Val Phe Leu Phe Arg Thr Lys Lys Lys His Pro Ala Val Ile 
            100                 105                 110         


Tyr Met Ala Asn Leu Ala Leu Ala Asp Leu Leu Ser Val Ile Trp Phe 
        115                 120                 125             


Pro Leu Lys Ile Ala Tyr His Ile His Gly Asn Asn Trp Ile Tyr Gly 
    130                 135                 140                 


Glu Ala Leu Cys Asn Val Leu Ile Gly Phe Phe Tyr Gly Asn Met Tyr 
145                 150                 155                 160 


Cys Ser Ile Leu Phe Met Thr Cys Leu Ser Val Gln Arg Tyr Trp Val 
                165                 170                 175     


Ile Val Asn Pro Met Gly His Ser Arg Lys Lys Ala Asn Ile Ala Ile 
            180                 185                 190         


Gly Ile Ser Leu Ala Ile Trp Leu Leu Ile Leu Leu Val Thr Ile Pro 
        195                 200                 205             


Leu Tyr Val Val Lys Gln Thr Ile Phe Ile Pro Ala Leu Asn Ile Thr 
    210                 215                 220                 


Thr Cys His Asp Val Leu Pro Glu Gln Leu Leu Val Gly Asp Met Phe 
225                 230                 235                 240 


Asn Tyr Phe Leu Ser Leu Ala Ile Gly Val Phe Leu Phe Pro Ala Phe 
                245                 250                 255     


Leu Thr Ala Ser Ala Tyr Val Leu Met Ile Arg Met Leu Arg Ser Ser 
            260                 265                 270         


Ala Met Asp Glu Asn Ser Glu Lys Lys Arg Lys Arg Ala Ile Lys Leu 
        275                 280                 285             


Ile Val Thr Val Leu Ala Met Tyr Leu Ile Cys Phe Thr Pro Ser Asn 
    290                 295                 300                 


Leu Leu Leu Val Val His Tyr Phe Leu Ile Lys Ser Gln Gly Gln Ser 
305                 310                 315                 320 


His Val Tyr Ala Leu Tyr Ile Val Ala Leu Cys Leu Ser Thr Leu Asn 
                325                 330                 335     


Ser Cys Ile Asp Pro Phe Val Tyr Tyr Phe Val Ser His Asp Phe Arg 
            340                 345                 350         


Asp His Ala Lys Asn Ala Leu Leu Cys Arg Ser Val Arg Thr Val Lys 
        355                 360                 365             


Gln Met Gln Val Ser Leu Thr Ser Lys Lys His Ser Arg Lys Ser Ser 
    370                 375                 380                 


Ser Tyr Ser Ser Ser Ser Thr Thr Val Lys Thr Ser Tyr 
385                 390                 395         


<210>  3
<211>  399
<212>  PRT
<213>  Mus musculus

<400>  3

Met Arg Ser Leu Ser Leu Ala Trp Leu Leu Gly Gly Ile Thr Leu Leu 
1               5                   10                  15      


Ala Ala Ser Val Ser Cys Ser Arg Thr Glu Asn Leu Ala Pro Gly Arg 
            20                  25                  30          


Asn Asn Ser Lys Gly Arg Ser Leu Ile Gly Arg Leu Glu Thr Gln Pro 
        35                  40                  45              


Pro Ile Thr Gly Lys Gly Val Pro Val Glu Pro Gly Phe Ser Ile Asp 
    50                  55                  60                  


Glu Phe Ser Ala Ser Ile Leu Thr Gly Lys Leu Thr Thr Val Phe Leu 
65                  70                  75                  80  


Pro Val Val Tyr Ile Ile Val Phe Val Ile Gly Leu Pro Ser Asn Gly 
                85                  90                  95      


Met Ala Leu Trp Ile Phe Leu Phe Arg Thr Lys Lys Lys His Pro Ala 
            100                 105                 110         


Val Ile Tyr Met Ala Asn Leu Ala Leu Ala Asp Leu Leu Ser Val Ile 
        115                 120                 125             


Trp Phe Pro Leu Ala Ile Ala Tyr His Leu His Gly Asn Asn Trp Val 
    130                 135                 140                 


Tyr Gly Glu Ala Leu Cys Lys Val Leu Ile Gly Phe Phe Tyr Gly Asn 
145                 150                 155                 160 


Met Tyr Cys Ser Ile Leu Phe Met Thr Cys Leu Ser Val Gln Arg Tyr 
                165                 170                 175     


Trp Val Ile Val Asn Pro Met Gly His Pro Arg Lys Lys Ala Asn Ile 
            180                 185                 190         


Ala Val Gly Val Ser Leu Ala Ile Trp Leu Leu Ile Phe Leu Val Thr 
        195                 200                 205             


Ile Pro Leu Tyr Val Met Lys Gln Thr Ile Tyr Ile Pro Ala Leu Asn 
    210                 215                 220                 


Ile Thr Thr Cys His Asp Val Leu Pro Glu Glu Val Leu Val Gly Asp 
225                 230                 235                 240 


Met Phe Asn Tyr Phe Leu Ser Leu Ala Ile Gly Val Phe Leu Phe Pro 
                245                 250                 255     


Ala Ile Leu Thr Ala Ser Ala Tyr Val Leu Met Ile Lys Thr Leu Arg 
            260                 265                 270         


Ser Ser Ala Met Asp Glu His Ser Glu Lys Lys Arg Gln Arg Ala Ile 
        275                 280                 285             


Arg Leu Ile Ile Thr Val Leu Ala Met Tyr Phe Ile Cys Phe Ala Pro 
    290                 295                 300                 


Ser Asn Leu Leu Leu Val Val His Tyr Phe Leu Ile Lys Thr Gln Arg 
305                 310                 315                 320 


Gln Ser His Val Tyr Ala Leu Tyr Leu Val Ala Leu Cys Leu Ser Thr 
                325                 330                 335     


Leu Asn Ser Cys Ile Asp Pro Phe Val Tyr Tyr Phe Val Ser Lys Asp 
            340                 345                 350         


Phe Arg Asp His Ala Arg Asn Ala Leu Leu Cys Arg Ser Val Arg Thr 
        355                 360                 365             


Val Asn Arg Met Gln Ile Ser Leu Ser Ser Asn Lys Phe Ser Arg Lys 
    370                 375                 380                 


Ser Gly Ser Tyr Ser Ser Ser Ser Thr Ser Val Lys Thr Ser Tyr 
385                 390                 395                 


<210>  4
<211>  397
<212>  PRT
<213>  Rattus rattus

<400>  4

Met Arg Ser Leu Ser Leu Ala Trp Leu Leu Gly Gly Ile Thr Leu Leu 
1               5                   10                  15      


Ala Ala Ser Ala Ser Cys Asn Arg Thr Val Asn Ala Pro Gly Pro Asn 
            20                  25                  30          


Ser Lys Gly Arg Ser Leu Ile Gly Arg Leu Asp Thr Pro Pro Pro Ile 
        35                  40                  45              


Thr Gly Lys Gly Ala Pro Val Glu Pro Gly Phe Ser Val Asp Glu Phe 
    50                  55                  60                  


Ser Ala Ser Val Leu Thr Gly Lys Leu Thr Thr Val Phe Leu Pro Val 
65                  70                  75                  80  


Ile Tyr Ile Ile Val Phe Val Ile Gly Leu Pro Ser Asn Gly Met Ala 
                85                  90                  95      


Leu Trp Val Phe Phe Phe Arg Thr Lys Lys Lys His Pro Ala Val Ile 
            100                 105                 110         


Tyr Met Ala Asn Leu Ala Leu Ala Asp Leu Leu Ser Val Ile Trp Phe 
        115                 120                 125             


Pro Leu Lys Ile Ser Tyr His Leu His Gly Asn Asp Trp Thr Tyr Gly 
    130                 135                 140                 


Asp Ala Leu Cys Lys Val Leu Ile Gly Phe Phe Tyr Gly Asn Met Tyr 
145                 150                 155                 160 


Cys Ser Ile Leu Phe Met Thr Cys Leu Ser Val Gln Arg Tyr Trp Val 
                165                 170                 175     


Ile Val Asn Pro Met Gly His Ser Arg Lys Arg Ala Asn Ile Ala Val 
            180                 185                 190         


Gly Val Ser Leu Ala Ile Trp Leu Leu Ile Phe Leu Val Thr Ile Pro 
        195                 200                 205             


Leu Tyr Val Met Arg Gln Thr Ile Tyr Ile Pro Ala Leu Asn Ile Thr 
    210                 215                 220                 


Thr Cys His Asp Val Leu Pro Glu Glu Val Leu Val Gly Asp Met Phe 
225                 230                 235                 240 


Ser Tyr Phe Leu Ser Leu Ala Ile Gly Val Phe Leu Phe Pro Ala Leu 
                245                 250                 255     


Leu Thr Ala Ser Ala Tyr Val Leu Met Ile Lys Thr Leu Arg Ser Ser 
            260                 265                 270         


Ala Met Asp Glu His Ser Glu Lys Lys Arg Arg Arg Ala Ile Arg Leu 
        275                 280                 285             


Ile Ile Thr Val Leu Ser Met Tyr Phe Ile Cys Phe Ala Pro Ser Asn 
    290                 295                 300                 


Val Leu Leu Val Val His Tyr Phe Leu Ile Lys Ser Gln Arg Gln Ser 
305                 310                 315                 320 


His Val Tyr Ala Leu Tyr Leu Val Ala Leu Cys Leu Ser Thr Leu Asn 
                325                 330                 335     


Ser Cys Ile Asp Pro Phe Val Tyr Tyr Phe Val Ser Lys Asp Phe Arg 
            340                 345                 350         


Asp Gln Ala Arg Asn Ala Leu Leu Cys Arg Ser Val Arg Thr Val Lys 
        355                 360                 365             


Arg Met Gln Ile Ser Leu Thr Ser Asn Lys Phe Ser Arg Lys Ser Ser 
    370                 375                 380                 


Ser Tyr Ser Ser Ser Ser Thr Ser Val Lys Thr Ser Tyr 
385                 390                 395         


<210>  5
<211>  903
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(900)

<400>  5
atg cgg agc ccc agc gcg gcg tgg ctg ctg ggg gcc gcc atc ctg cta       48
Met Arg Ser Pro Ser Ala Ala Trp Leu Leu Gly Ala Ala Ile Leu Leu         
1               5                   10                  15              

gca gcc tct ctc tcc tgc agt ggc acc atc caa gga acc aat aga tcc       96
Ala Ala Ser Leu Ser Cys Ser Gly Thr Ile Gln Gly Thr Asn Arg Ser         
            20                  25                  30                  

tct aaa gga aga agc ctt att ggt aag gtt gat ggc aca tcc cac gtc      144
Ser Lys Gly Arg Ser Leu Ile Gly Lys Val Asp Gly Thr Ser His Val         
        35                  40                  45                      

act gga aaa gga gtt aca gtt gaa aca gtc ttt tct gtg gat gag ttt      192
Thr Gly Lys Gly Val Thr Val Glu Thr Val Phe Ser Val Asp Glu Phe         
    50                  55                  60                          

tct gca tct gtc ctc act gga aaa gtc gac aaa act cac aca tgc cca      240
Ser Ala Ser Val Leu Thr Gly Lys Val Asp Lys Thr His Thr Cys Pro         
65                  70                  75                  80          

ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc      288
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe         
                85                  90                  95              

ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc      336
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val         
            100                 105                 110                 

aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc      384
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe         
        115                 120                 125                     

aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg      432
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro         
    130                 135                 140                         

cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc      480
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr         
145                 150                 155                 160         

gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc      528
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val         
                165                 170                 175             

tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc      576
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala         
            180                 185                 190                 

aaa ggg cag ccc cga gag cca cag gtg tac acc ctg ccc cca tcc cgg      624
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg         
        195                 200                 205                     

gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc      672
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly         
    210                 215                 220                         

ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg      720
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro         
225                 230                 235                 240         

gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc      768
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser         
                245                 250                 255             

ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag      816
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln         
            260                 265                 270                 

ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac      864
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His         
        275                 280                 285                     

tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa tga                  903
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                         
    290                 295                 300                         


<210>  6
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Ser Pro Ser Ala Ala Trp Leu Leu Gly Ala Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ala Ser Leu Ser Cys Ser Gly Thr Ile Gln Gly Thr Asn Arg Ser 
            20                  25                  30          


Ser Lys Gly Arg Ser Leu Ile Gly Lys Val Asp Gly Thr Ser His Val 
        35                  40                  45              


Thr Gly Lys Gly Val Thr Val Glu Thr Val Phe Ser Val Asp Glu Phe 
    50                  55                  60                  


Ser Ala Ser Val Leu Thr Gly Lys Val Asp Lys Thr His Thr Cys Pro 
65                  70                  75                  80  


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                85                  90                  95      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            100                 105                 110         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        115                 120                 125             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    130                 135                 140                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
145                 150                 155                 160 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                165                 170                 175     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            180                 185                 190         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        195                 200                 205             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    210                 215                 220                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
225                 230                 235                 240 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                245                 250                 255     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            260                 265                 270         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        275                 280                 285             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295                 300 


<210>  7
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide

<400>  7

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  8
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  8
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc     60

tcctgtaagg gttctggata caactttatc agccactgga tcggctgggt gcgccagatg    120

cccgggaaag gcctggagtg gatggggatg atctatcctg gtgactctga taccagatac    180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcaa taccgcctac    240

ctgcagtgga gaagcctgaa ggcctcggac accgccatgt atttctgtgc gagacatgga    300

ggtataactg gaactacctt ctactacgac ttcggtatgg acgtctgggg ccaagggacc    360

acggtcaccg tctcctca                                                  378


<210>  9
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Asn Phe Ile Ser His 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Ile Thr Gly Thr Thr Phe Tyr Tyr Asp Phe Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  10
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  10
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacagac ggccaggatc     60

acctgctctg gagatgcatt gccaaagcaa tatgcttctt ggtaccagca gaagccaggc    120

caggcccctc tattggtgat atatagagac agtgagaggc cctcagggct ccctgagcga    180

ttctctggct ccagctcagg gacaacagtc acgttgacca tcagtggagt ccaggcagaa    240

gacgaggctg actattactg tcaatcggca gacagcggtg gttcttatgt cttcggcact    300

gggaccaagg tcaccgtcct a                                              321


<210>  11
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr 
        35                  40                  45              


Arg Asp Ser Glu Arg Pro Ser Gly Leu Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Gly Gly Ser Tyr 
                85                  90                  95      


Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  12
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  12
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagt ccggggagtc tctgaagatc     60

tcctgtaagg gttctggata cagcttttcc aactactgga tcggctgggt gcgccagatg    120

cccgggaaag gcctggagtg gatgggaatc atctatcctg gtgactctga taccagatac    180

agcccgtcct tccagggcca ggtcaccatc tcagccgaca agtccatcag aaccgcctac    240

ctacagtgga gcagtttgaa ggcctcggac accgccatgt attactgtgc gagacataaa    300

ggtataactg gaactacctt ctactacgac tacggcatgg acgtctgggg ccaagggacc    360

acggtcaccg tctcctca                                                  378


<210>  13
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ser Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Arg Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Lys Gly Ile Thr Gly Thr Thr Phe Tyr Tyr Asp Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  14
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  14
tcctatgagt tgacacagcc accctcggtg tcagtgtccc caggacagac ggccaggatc     60

acctgctctg gagaagcttt gccaaaacaa tatgcttctt ggtaccagca gaagccaggc    120

caggcccctg tcttggtgat atatagagac actgagaggc cctcagggat ccctgagcga    180

ttctctggct ccagctcagg gacaacagtc acgttgacca tcagtggagt ccaggcagaa    240

gacgaggctg actattactg tcaatcagca gacagcaatg gtgcttatgt cttcggaact    300

gggaccaggg tcaccgtcct a                                              321


<210>  15
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Glu Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Arg Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Asn Gly Ala Tyr 
                85                  90                  95      


Val Phe Gly Thr Gly Thr Arg Val Thr Val Leu 
            100                 105         


<210>  16
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  16
gaggtgcagt tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc     60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg    120

cccgggaaag gcctggagtg gatgggaatc atctatcctg gtgactctga taccagatac    180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag aaccgcctac    240

ctacagtgga gcagtttgaa ggcctcggac accgccatgt attactgtgc gagacataaa    300

ggtataactg gaactacctt ctactacgac tacggcatgg acgtctgggg ccaagggacc    360

acggtcaccg tctcctca                                                  378


<210>  17
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Arg Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Lys Gly Ile Thr Gly Thr Thr Phe Tyr Tyr Asp Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  18
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  18
tcctatgagt tgacacagcc accctcggtg tcagtgtccc caggacagac ggccaggatc     60

acctgctctg gagaagcttt gccaaagcaa tatgcttctt ggtaccagca gaagccaggc    120

caggcccctg tcttggtgat atataaagac agtgagaggc cctcagggat ccctgagcga    180

ttctctggct ccagctcagg gacaacagtc acgttgacca tcagtggagt ccaggcagaa    240

gacgaggctg actattactg tcaatcagca gacagcaatg gtgcttatgt cttcggaact    300

ggaaccaagg tcaccgtcct a                                              321


<210>  19
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  19

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Glu Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Asn Gly Ala Tyr 
                85                  90                  95      


Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  20
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  20
tcctatgagc tgactcagcc actctcagtg tcagtggccc tgggacagac ggccaggatt     60

acctgtgggg gaaacaacat tggaagtaaa aatgtgcact ggtaccagca gaagccaggc    120

caggcccctg tgctggtcat ctatagggat agcaaccggc cctctgggat ccctgagcga    180

ttctctggct ccaactcggg gaacacggcc accctgacca tcagcagagc ccaagccggg    240

gatgaggctg actattactg tcaggtgtgg gacagcagca ctgcggtatt cggcggaggg    300

accaagctga ccgtccta                                                  318


<210>  21
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Arg Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Thr Ala Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  22
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  22
caggtgcaac tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggata caccttcacc ggctactttt ttcactgggt gcgacaggcc    120

cctggacaag ggcttgagtg ggtgggatgg atcaacccta acagtggtgc cacacacttt    180

gcacagaaat ttcagggcag ggtcaccatg accagggaca cgtccatcag tacagcctac    240

atggaactga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagatggc    300

tccaactgga accgcgacta cggtatggac gtctggggcc aggggaccac ggtcaccgtc    360

tcctca                                                               366


<210>  23
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Phe Phe His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Ala Thr His Phe Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Asn Trp Asn Arg Asp Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  24
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  24
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc     60

tcttgttctg gaagcagctc caacatcgga attaatcatg tatattggta ccagcaactc    120

ccaggaacgg cccccaaaat cttcatctat aggaataatc agcggccctc aggggtccct    180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg    240

tccgaggatg aggctgatta ttactgtgca gtatgggatg acagtctgag tggtgtggta    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  25
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  25

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn 
            20                  25                  30          


His Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Ile Phe 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  26
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  26
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatctg    300

ggagcagcag ctggtactgg ttttgactac tggggccagg gaaccctggt caccgtctcc    360

tca                                                                  363


<210>  27
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Ala Ala Ala Gly Thr Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  28
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  28
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc     60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact cctcatttat gacaataata agcgaccctc agggattcct    180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag    240

actggggacg aggccgatta ttactgcgga acatgggata gcagcctgag tgctggtgtg    300

gtattcggcg gagggaccaa gctgaccgtc cta                                 333


<210>  29
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  29

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  30
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  30
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc     60

acctgtgcca tctccgggga cagtgtctct agcaacagag ctgcttggaa ctggatcagg    120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat    180

aatgattttg cagtatctgt gagaagtcga ataaccatca ccccagacac atccaagaac    240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca    300

agagatagga acagtggcta ctactactac ggtttggacg tctggggcca agggaccacg    360

gtcaccgtct cctca                                                     375


<210>  31
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Arg Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Phe Ala 
    50                  55                  60                  


Val Ser Val Arg Ser Arg Ile Thr Ile Thr Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Arg Asn Ser Gly Tyr Tyr Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  32
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  32
aaaatagtga tgacgcagtc tccagctacc ctgtctgtgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagt aacaacttag cctggtatca gcagaaacct    120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc    180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcaccag cctacagtct    240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  33
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  33

Lys Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Thr Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  34
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  34
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc     60

acctgtgcca tctccgggga cagtgtctct agcaacagag ctgcttggaa ctggatcagg    120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat    180

aatgatcatg cagtatctgt gaaaagtcga ataaccatca ccccagacac atccaagaac    240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca aagctgtgta ttactgtgca    300

agagatagga acagtggcta ctactactac ggtttggacg tctggggcca agggaccacg    360

gtcaccgtct cctca                                                     375


<210>  35
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Arg Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp His Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Thr Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Lys Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Arg Asn Ser Gly Tyr Tyr Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  36
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  36
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagt aacaacttag cctggtacca gcagaaacct    120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc    180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcaccag cctacagtct    240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  37
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  37

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Thr Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  38
<211>  473
<212>  PRT
<213>  Artificial sequence

<220>
<223>  1A1 human-mouse chimera

<400>  38

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
        35                  40                  45              


Tyr Asn Phe Ile Ser His Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Met Gly Met Ile Tyr Pro Gly Asp Ser Asp Thr 
65                  70                  75                  80  


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
                85                  90                  95      


Ser Ile Asn Thr Ala Tyr Leu Gln Trp Arg Ser Leu Lys Ala Ser Asp 
            100                 105                 110         


Thr Ala Met Tyr Phe Cys Ala Arg His Gly Gly Ile Thr Gly Thr Thr 
        115                 120                 125             


Phe Tyr Tyr Asp Phe Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
145                 150                 155                 160 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
                165                 170                 175     


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
            180                 185                 190         


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
        195                 200                 205             


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
    210                 215                 220                 


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
225                 230                 235                 240 


Lys Val Asp Lys Thr Val Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
                245                 250                 255     


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
    290                 295                 300                 


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
            340                 345                 350         


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
        355                 360                 365             


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
    370                 375                 380                 


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
385                 390                 395                 400 


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
                405                 410                 415     


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
            420                 425                 430         


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
        435                 440                 445             


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
    450                 455                 460                 


Lys Ser Leu Ser His Ser Pro Gly Lys 
465                 470             


<210>  39
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain consensus


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be Thr or Met

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be Glu or Asp

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be Ser or Tyr

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa can be Leu or Val

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be Arg or Lys

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa can be Thr or Ser

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be Ile or Leu

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa can be Asn or Gly

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa can be Ala or Ser

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa can be Tyr or none

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be Arg or Lys

<400>  39

Ser Tyr Glu Leu Xaa Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Xaa Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Xaa Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Xaa Leu Val Ile Tyr 
        35                  40                  45              


Xaa Asp Xaa Glu Arg Pro Ser Gly Xaa Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Xaa Gly Xaa Xaa 
                85                  90                  95      


Tyr Val Phe Gly Thr Gly Thr Xaa Val Thr Val Leu 
            100                 105             


<210>  40
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain consensus


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be Pro or Ser

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be Ser or Asn

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be Ser or Ile or Thr

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be Asn or Ser

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be Tyr or His

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa can be Ile or Met

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa can be Arg or Asn

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be Ser or Arg

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa can be Tyr or Phe

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa can be Lys or Gly

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa can be Tyr or Phe

<400>  40

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Xaa Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Xaa Phe Xaa Xaa Xaa 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Xaa Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Xaa Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Xaa Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Xaa Cys 
                85                  90                  95      


Ala Arg His Xaa Gly Ile Thr Gly Thr Thr Phe Tyr Tyr Asp Xaa Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  41
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain consensus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Lys or Glu

<400>  41

Xaa Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Thr Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  42
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain consensus


<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa can be Phe or His

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa can be Arg or Lys

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  Xaa can be Thr or Lys

<400>  42

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Arg Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Xaa Ala 
    50                  55                  60                  


Val Ser Val Xaa Ser Arg Ile Thr Ile Thr Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Xaa Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Arg Asn Ser Gly Tyr Tyr Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  43
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag/Fc construct

<400>  43

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Asp Tyr Lys Asp Asp Asp Asp Lys Asp Lys Thr 
            20                  25                  30          


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        35                  40                  45              


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    50                  55                  60                  


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
65                  70                  75                  80  


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                85                  90                  95      


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            100                 105                 110         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        115                 120                 125             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    130                 135                 140                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
145                 150                 155                 160 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                165                 170                 175     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            180                 185                 190         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        195                 200                 205             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
225                 230                 235                 240 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250                 255     


